Porin



Porin or Outer Membrane Proteins (Omps) act as channels which allow passive diffusion of sugars, ions and amino acids. They are beta barrel proteins which traverse the cell membrane. In E. coli they are named according to their genes: C, F, G (OmpC, OmpF, Ompg). Voltage-Dependent Anion Channel (VDAC) is ion channel Omp found in outer mitochondrial membrane. In Pseudomonas aeruginosa the porin gene products are named OprD, OprK, OprP. The images at the left and at the right correspond to one representative porin structure, i.e. crystal structure osmoporin OmpC from Escherichia coli (2j1n). OmpC has three beta-barrels associated to form a tight trimer.

Porin
2xe5, 2xe1, 2xe2, 2xe3, 2j1n – EcOmpC – Escherichia coli

3k19, 3k1b, 2zfg, 1omf, 2omf, 1opf – EcOmpF

1hxt, 1hxu, 1hxx, 1bt9, 1gfm, 1gfn, 1gfo, 1gfp, 1gfq, 1mpf – EcOmpF (mutant)

2iwv, 2iww, 2f1c - EcOmpG

2wjq, 2wjr – EcOmp NANC

1pho - EcOmp

3a2r – NmOmpB – Neisseria meningitides

3jty – Omp – Pseudomonas fluorescens

2qtk – PaOprK – Pseudomonas aeruginosa

2odj - PaOprD

2v9u – MsOmp rim domain – Mycobacteria smegmatis

1uun – MsOmp (mutant)

2fgr - DaOmp32 - Delftia acidovorans

1a0s, 1mpr - StOmp - Salmonella typhimurium

2prn, 1bh3, 3prn, 5prn, 6prn, 7prn, 8prn – RbOmp (mutant) - Rhodopseudomonas blastica

1prn - RbOmp

1osm – OmpK36 – Klebsiella pneumoniae

2por, 3por – Omp – Rhodobacter capsulatus

Porin + polypeptides
2j4u - EcOmpC + lactotransferrin fragment

2zld - EcOmpF + colicin E3

3o0e - EcOmpF + colicin peptide

1h6s - RbOmp + inserted sequence

Porin + various compounds
3hw9, 3hwb - EcOmpF + ions ,br /. 3fyx - Ec~OmpF + dibenzo-18-crown-6

1af6, 1mpq, 1mpm, 1mpn, [1mpo]] - EcOmp LAMB + sugars

3a2s, 3a2t - NmOmpB + sugars

3a2u - NmOmpB + AMPPNP

2o4v - PaOprP + phosphate

2fgq - DaOmp32 + malate

1e54 - Omp32 + sulfate - Comamonas acidovorans

1oh2, 1a0t - StOmp + sucrose

Voltage-Dependent Anion Channel
2jk4 – hVDAC-1 – human

2k4t - hVDAC-1 - NMR

3emn – VDAC-1 - mouse